STOCKHOLM (Nyhetsbyrån Direkt) Forskningsbolaget Cantargia har inlett behandling av den första patienten i en utökning av Canfour-studien i fas 2a vid

Cantargias antikropp CAN04 (nidanilimab) studeras i en öppen tre-armad fas IIa klinisk studie, CANFOUR. I studien undersöks CAN04 som monoterapi eller i kombinationer med cellgifter i patienter med icke-småcellig lungcancer (NSCLC) eller bukspottkörtelcancer (PDAC).

A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors (CANFOUR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. In the CANFOUR part examining PDAC, 9 patients in the first cohort of 31 are currently on treatment with CAN04 in combination with gemcitabine and nab-paclitaxel. An interim analysis of 20 patients in October 2020 showed a 40% response rate (including 2 patients that had not been treated long enough for a second confirmatory CT-scan), which is higher than 23% reported as historical control 1 . Cantargia´s antibody CAN04 (nidanilimab) is investigated in an open label three-armed phase IIa clinical trial, CANFOUR. Here, CAN04 is examined as monotherapy or in chemotherapy combinations in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC).

Canfour can04

CAN04 increased the anti-tumor effects in mice when combined with different registered platinum-based therapies (cisplatin, carboplatin or oxaliplatin) in either a patient-derived NSCLC model or CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining combination with two different frequently used chemotherapy regimes in patients with non-small cell lung The main project, the antibody CAN04, is being studied in the clinical phase I/IIa CANFOUR study with a primary focus on non-small cell lung cancer and pancreatic cancer. The study is focused on CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining first line chemotherapy combination with two different standard regimes in patients with non-small cell lung cancer (NSCLC) or pancreatic cancer (PDAC), as well as monotherapy in late stage patients (www.clinicaltrials.gov). The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1a and IL-1ß signaling. Thereby, CAN04 can counteract the contribution of the IL-1 CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in patients with non-small cell lung cancer or pancreatic cancer, as well as monotherapy in late stage patients. CAN04 is presently investigated in combination with pembrolizumab (a common immunotherapy) to study the combination of these two immunotherapies.

The antibody CAN04 binds strongly to the target IL1RAP and functions both though ADCC as well as blocking IL-1α and IL-1β signaling. Thereby, CAN04 can counteract the contribution of the IL-1

08.10.2020 - STOCKHOLM, Oct. 8, 2020 /PRNewswire/ - Cantargia AB today announced that all 31 pancreatic cancer (PDAC) patients planned in the CANFOUR trial investigating combination of CAN04 … Etiketter:Bukspottkörtelcancer, CAN04, CANFOUR, Cantargia, Icke-småcellig lungcancer. Extensionsdelen har designats för att ge ytterligare information som kompletterar den primära kohorten av 31 patienter.

CAN04 studeras för närvarande i en öppen trearmad fas I/IIa klinisk prövning, CANFOUR. Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov).

Fas I – doseskalering med säkerhetsutvärdering. Initierades efter Can04 är en antikropp som har IL-1RAP som mål. Verkningsmekanism tros vara en minskning av inflammation i tumörens´mikromiljön + ADCC + CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker kombination med två olika cellgiftsbehandlingar i patienter med Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 undersöks i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker Prekliniska data visar att CAN04 kan öka effekten av cellgifter. CAN04 studeras i en öppen fas I/IIa klinisk studie, CANFOUR, som undersöker Cantargia's Phase IIa CANFOUR trial investigates CAN04 in a combination with a different chemotherapy (platinum-based as opposed to Redeye bedömer att uppdaterade data från CANFOUR-studien ytterligare stärker utsikterna för antikroppsbehandlingen CAN04 och kan tala CAN04 is investigated in an open label phase I/IIa clinical trial, CANFOUR, examining two different first line chemotherapy combinations in Vi tror att den trend som CAN04 visade upp i de preliminära data som Även om CANFOUR-studien, som pågått sedan 2017, har dragits med patient with pancreatic cancer (PDAC) has started treatment in the phase IIa extension part of the CANFOUR trial, investigating combination of CAN04 and First part of CANFOUR is nearing completion – Updated 16 May 2018 Cantargia's lead candidate is the antibody CAN04, which has a dual mechanism of Syftet är en utökad satsning på Cantargias huvudprojekt CAN04 lovande subgruppen patienter i den pågående kliniska studien CANFOUR. Cantargia utvecklar antikroppen CAN04 för cancerbehandling. CAN04 undersöks i den kliniska fas I/IIa-studien CANFOUR.

CAN04-antikroppen är riktad mot IL1RAP som finns i ett stort antal cancerformer. De första sjukhusen i den kliniska fas I/IIa prövningen CANFOUR initierades nyligen och rekrytering av patienter pågår.
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Nio av dessa patienter behandlas fortfarande vilket fortlöpande ger … 2021-03-31 2021-03-10 2019-07-05 Cantargia presents clinical data from its ongoing CANFOUR trial at ESMO Cantargia AB (publ) today announced that interim results from its clinical Phase I/II trial of lead candidate CAN04 (nidanilimab) will be presented in a poster presentation at the ESMO Congress 2018 in … Behandling på tværs af kræftsygdomme, Brystkræft, Bugspytkirtelkræft, Endetarmskræft, Lungekræft, ikke småcellet, Tyktarmskræft.

Här undersöks CAN04 både som monoterapi liksom i kombinationsterapi med två olika cellgiftsregimer i patienter med icke-småcellig lungcancer eller bukspottskörtelcancer (www.clinicaltrials.gov). I den del av CANFOUR som innefattar PDAC behandlas fortfarande 9 av 31 patienter i den primära kohorten med CAN04 i kombination med gemcitabin och nab-paclitaxel.
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CANFOUR. 37 KB. Open-Label-Studie, Dosiseskalation gefolgt von Dosisexpansion, Sicherheits- und Tolerierbarkeitsstudie von CAN04, einem vollständig

Summary CANFOUR CAN04CLIN002.